Changes in metabolic parameters in patients with diabetic kidney disease depending on the status of D3

Abstract

Vitamin D has an indirect and direct impact on a variety of mechanisms that are associated with type 2 diabetes containing systemic inflammation, insulin disorders and pancreatic beta-cell dysfunction. Type 2 diabetes is a metabolic disease, which characterized by hyperglycemia on the background of insulin resistance and decreased insulin secretion. Chronic hyperglycemia can lead to damage and dysfunction of various organs, a striking example is a diabetic nephropathy. Diabetic nephropathy is specific kidney damage that occurs due to complications of diabetes and is accompanied by the formation of diffuse or nodular glomerulosclerosis, which can lead to terminal renal failure and requires the immediate substitution of renal therapy or renal transplantation.