Effects of durable proton pump inhibitors application on nitrite ions content in the blood serum and mucous membranes of the stomach and colon in rats

Abstract

Prolonged use of proton pump inhibitors leads to hypergastrinemia and dysbiosis and as a consequence to the development of the inflammatory process in the gastrointestinal tract. 7KH DLP of the work was to determine nitrite ions content in the blood serum and gastric and colon mucous membranes in rats with prolonged use of proton pump inhibitors Omeprazole and Pantoprazole. DWHULDO& D G PHWKRG&$ The studies were performed on 30 white non linear male rats weighing 160 180 g, divided into three groups of 10 animals in each. The control (group 1) animals were administered intraperitoneally water for injection within 28 days once a day. Group 2 was administered omeprazole. Group 3 was administered Pantoprazole. The content of nitrite ions in the blood serum and mucous membranes of the stomach and colon of rats was determined by the Griess method. For statistical data processing, Students t criterion for independent samples was applied.